Pseudomonas aeruginosa PA7, PSPA7_2743 (oprN)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PA7 GCF_000017205.1|latest
Locus Tag	PSPA7_2743
Name	oprN
Replicon	chromosome
Genomic location	2764960 - 2766378 (- strand)

Cross-References

RefSeq	YP_001348103.1
GI	152984713
Entrez	5359232
INSDC	ABR81896.1
NCBI Locus Tag	PSPA7_2743
UniParc	UPI0000D73028
UniProtKB Acc	A6V4W8
UniProtKB ID	A6V4W8_PSEA7
UniRef100	UniRef100_A6V4W8
UniRef50	UniRef50_Q88HD3
UniRef90	UniRef90_Q02MU4

Product

Feature Type	CDS
Coding Frame	1
Product Name	outer membrane protein OprN
Synonyms
Evidence for Translation
Charge (pH 7)	-7.52
Kyte-Doolittle Hydrophobicity Value	-0.315
Molecular Weight (kDa)	51.3
Isoelectric Point (pI)	5.00

Subcellular localization

Individual Mappings	Localization Confidence PMID Outer Membrane Class 3 20472543
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name	Definition	Accession	Model Type (?)	SNP	Cutoff	Bit Score	Percent Identity	CARD Version
OprN	OprN is the outer membrane channel component of the MexEF-OprN multidrug efflux complex. [PMID:10515918]	ARO:3000805	protein homolog model		Strict	863.6	97.46	3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5IUY	TRANSPORT PROTEIN	03/18/16	Structural insights of the outer-membrane channel OprN	Pseudomonas aeruginosa PAO1	2.29	X-RAY DIFFRACTION	97.7
5NSW	MEMBRANE PROTEIN	04/27/17	Xenon for tunnelling analysis of the efflux pump component OprN.	Pseudomonas aeruginosa PAO1	2.5	X-RAY DIFFRACTION	97.7
5AZO	MEMBRANE PROTEIN	10/21/15	Crystal structure of a membrane protein from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	2.7	X-RAY DIFFRACTION	97.7
5AZP	MEMBRANE PROTEIN	10/21/15	Crystal structure of a membrane protein from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	1.69	X-RAY DIFFRACTION	97.7

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 294 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003062 (529 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPA7_2743 Search term: oprN Search term: outer membrane protein OprN

Human Homologs

References