Pseudomonas aeruginosa PA7, PSPA7_4988 (murF)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PA7
GCF_000017205.1|latest |
| Locus Tag |
PSPA7_4988
|
| Name |
murF
|
| Replicon | chromosome |
| Genomic location | 5144746 - 5146122 (- strand) |
Cross-References
| RefSeq | YP_001350324.1 |
| GI | 152988693 |
| Entrez | 5359819 |
| NCBI Locus Tag | PSPA7_4988 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanine ligase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -2.40 |
| Kyte-Doolittle Hydrophobicity Value | 0.172 |
| Molecular Weight (kDa) | 47346.5 |
| Isoelectric Point (pI) | 6.59 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 4CVL | LIGASE | 03/28/14 | PaMurF in complex with AMP-PNP | PSEUDOMONAS AERUGINOSA PAO1 | 2.98 | X-RAY DIFFRACTION | 96.6 |
| 4CVK | LIGASE | 03/28/14 | PaMurF in complex with UDP-MurNAc-tripeptide (mDAP) | Pseudomonas aeruginosa PAO1; SYNTHETIC CONSTRUCT | 1.92 | X-RAY DIFFRACTION | 96.6 |
| 4CVM | LIGASE | 03/28/14 | PaMurF in complex with AMP-PNP and UDP-MurNAc-tripeptide (mDAP) | PSEUDOMONAS AERUGINOSA PAO1 | 2.06 | X-RAY DIFFRACTION | 96.6 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 578 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG004006 (534 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PSPA7_4988
Search term: murF
|
Human Homologs
References
No references are associated with this feature.