Pseudomonas aeruginosa PA7, PSPA7_5378 (higA)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PA7 GCF_000017205.1|latest
Locus Tag	PSPA7_5378
Name	higA
Replicon	chromosome
Genomic location	5541534 - 5541839 (- strand)

Cross-References

RefSeq	YP_001350708.1
GI	152987164
Entrez	5353959
INSDC	ABR84347.1
NCBI Locus Tag	PSPA7_5378
UniParc	UPI00015776B4
UniProtKB Acc	A6VCC3
UniProtKB ID	A6VCC3_PSEA7
UniRef100	UniRef100_A6VCC3
UniRef50	UniRef50_A6VCC3
UniRef90	UniRef90_A6VCC3

Product

Feature Type	CDS
Coding Frame	1
Product Name	addiction module antidote protein
Synonyms
Evidence for Translation
Charge (pH 7)	-5.29
Kyte-Doolittle Hydrophobicity Value	-0.175
Molecular Weight (kDa)	11184.5
Isoelectric Point (pI)	4.61

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6LB3	ANTITOXIN/DNA	11/13/19	Crystal structure of PA4674 in complex with its operator DNA (18bp) from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); SYNTHETIC CONSTRUCT	2.497	X-RAY DIFFRACTION	97.0
7CSW	ANTITOXIN/DNA	08/17/20	Pseudomonas aeruginosa antitoxin HigA with pa2440 promoter	Pseudomonas aeruginosa PAO1; Pseudomonas aeruginosa UCBPP-PA14	1.97	X-RAY DIFFRACTION	97.0
6JPI	ANTITOXIN/DNA	03/27/19	Crystal structure of PA4674 in complex with its operator DNA (28bp) from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); SYNTHETIC CONSTRUCT	3.143	X-RAY DIFFRACTION	97.0
7CSV	ANTITOXIN	08/17/20	Pseudomonas aeruginosa antitoxin HigA	Pseudomonas aeruginosa PAO1	1.71	X-RAY DIFFRACTION	97.0
7CSY	ANTITOXIN/DNA	08/17/20	Pseudomonas aeruginosa antitoxin HigA with higBA promoter	Pseudomonas aeruginosa PAO1; Pseudomonas aeruginosa UCBPP-PA14	2.29	X-RAY DIFFRACTION	97.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 223 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004324 (343 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPA7_5378 Search term: higA Search term: addiction module antidote protein

Human Homologs

References