Strain |
Pseudomonas aeruginosa M18
GCF_000226155.1|latest |
Locus Tag |
PAM18_1222
|
Name |
lasB
|
Replicon | chromosome |
Genomic location | 1337443 - 1338939 (+ strand) |
RefSeq | YP_005973811.1 |
GI | 386057289 |
Entrez | 12565251 |
NCBI Locus Tag | PAM18_1222 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
elastase LasB
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -1.48 |
Kyte-Doolittle Hydrophobicity Value | -0.271 |
Molecular Weight (kDa) | 53.7 |
Isoelectric Point (pI) | 6.74 |
Individual Mappings | |
Additional evidence for subcellular localization |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
7AJR | HYDROLASE | 09/29/20 | Virtual screening approach leading to the identification of a novel and tractable series of Pseudomonas aeruginosa elastase inhibitors | Pseudomonas aeruginosa | 1.75 | X-RAY DIFFRACTION | 100.0 |
3DBK | HYDROLASE | 06/01/08 | Pseudomonas aeruginosa elastase with phosphoramidon | Pseudomonas aeruginosa | 1.4 | X-RAY DIFFRACTION | 100.0 |
1EZM | HYDROLASE | 01/13/92 | THREE-DIMENSIONAL STRUCTURE OF THE ELASTASE OF PSEUDOMONAS AERUGINOSA AT 1.5 ANGSTROMS RESOLUTION | Pseudomonas aeruginosa | 1.5 | X-RAY DIFFRACTION | 100.0 |
8CR7 | HYDROLASE | 03/07/23 | Crystal structure of recombinant LasB from Pseudomonas aeruginosa PA7 | Pseudomonas aeruginosa PA7 | 1.5 | X-RAY DIFFRACTION | 95.9 |
7QH1 | HYDROLASE | 12/10/21 | Discovery and development of a novel inhaled antivirulence therapy for the treatment of Pseudomonas aeruginosa infections in patients with chronic respiratory disease | Pseudomonas aeruginosa | 2.74 | X-RAY DIFFRACTION | 100.0 |
1U4G | HYDROLASE | 07/25/04 | Elastase of Pseudomonas aeruginosa with an inhibitor | Pseudomonas aeruginosa | 1.4 | X-RAY DIFFRACTION | 100.0 |
6F8B | HYDROLASE | 12/12/17 | LasB bound to thiol based inhibitor | Pseudomonas aeruginosa | 1.3 | X-RAY DIFFRACTION | 100.0 |
7OC7 | HYDROLASE | 04/26/21 | LasB, alpha-alkyl-N-aryl mercaptoacetamide | Pseudomonas aeruginosa | 1.95 | X-RAY DIFFRACTION | 98.7 |
6FZX | HYDROLASE | 03/15/18 | LasB, hydroxymate Inhibitor Complex | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 100.0 |
4K89 | HYDROLASE | 04/18/13 | Crystal structure of Pseudomonas aeruginosa strain K solvent tolerant elastase | Pseudomonas aeruginosa | 1.39 | X-RAY DIFFRACTION | 99.7 |
8CR3 | HYDROLASE | 03/07/23 | Crystal structure of recombinant LasB from Pseudomonas aeruginosa PAO1 | Pseudomonas aeruginosa PAO1 | 1.12 | X-RAY DIFFRACTION | 98.4 |
7NLK | HYDROLASE | 02/22/21 | LasB, N-aryl-2-butylmercaptoacetamide | Pseudomonas aeruginosa (strain UCBPP-PA14) | 1.7 | X-RAY DIFFRACTION | 98.7 |
7NLM | HYDROLASE | 02/22/21 | LasB, N-aryl-2-butylmercaptoacetamide | Pseudomonas aeruginosa (strain UCBPP-PA14) | 1.65 | X-RAY DIFFRACTION | 98.7 |
8CR4 | HYDROLASE | 03/07/23 | Crystal structure of recombinant LasBArtif from Pseudomonas aeruginosa AZPAE14816 | Pseudomonas aeruginosa | 0.91 | X-RAY DIFFRACTION | 94.9 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
N-(1-Carboxy-3-Phenylpropyl)Phenylalanyl-Alpha-Asparagine | DB02307 | DrugBank | 5.1.4 | P14756 | Elastase | 100.0 | 498 | 6.5e-289 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 114 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001959 (310 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PAM18_1222
Search term: lasB
Search term: elastase LasB
|