Pseudomonas stutzeri RCH2, Psest_0314

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas stutzeri RCH2
GCF_000327065.1|latest
Locus Tag
Psest_0314
Name
Replicon chromosome
Genomic location 337219 - 338625 (- strand)

Cross-References

RefSeq YP_007238555.1
GI 431925521
EC Number 3.3.1.1
Entrez 14298169
INSDC AGA84925.1
NCBI Locus Tag Psest_0314
UniParc UPI0002A18D45
UniProtKB Acc L0GHN4
UniProtKB ID L0GHN4_PSEST
UniRef100 UniRef100_L0GHN4
UniRef50 UniRef50_Q4K4H7
UniRef90 UniRef90_A4XPF3

Product

Feature Type CDS
Coding Frame 1
Product Name
adenosylhomocysteinase
Synonyms
Evidence for Translation
Charge (pH 7) -11.58
Kyte-Doolittle Hydrophobicity Value -0.103
Molecular Weight (kDa) 50934.0
Isoelectric Point (pI) 5.22

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6F3P HYDROLASE 11/28/17 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa in complex with 3'-deoxyadenosine and K+ cation Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.35 X-RAY DIFFRACTION 90.8
6F3O HYDROLASE 11/28/17 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa complexed with adenine, K+ and Zn2+ cations Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.75 X-RAY DIFFRACTION 90.8
7ZD4 HYDROLASE 03/29/22 Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase soaked with Cu+ ions Pseudomonas aeruginosa PAO1 2.14 X-RAY DIFFRACTION 90.8
6F3N HYDROLASE 11/28/17 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa cocrystallized with SAH in the presence of K+ and Zn2+ cations Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.85 X-RAY DIFFRACTION 90.8
7ZD1 HYDROLASE 03/29/22 Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase inhibited by Hg2+ ions Pseudomonas aeruginosa PAO1 1.56 X-RAY DIFFRACTION 90.8
7ZD3 HYDROLASE 03/29/22 Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase inhibited by Zn2+ ions Pseudomonas aeruginosa PAO1 1.9 X-RAY DIFFRACTION 90.8
7ZD0 HYDROLASE 03/29/22 Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase inhibited by Cd2+ ions Pseudomonas aeruginosa PAO1 1.87 X-RAY DIFFRACTION 90.8
7ZD2 HYDROLASE 03/29/22 Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase inhibited by Co2+ ions. Pseudomonas aeruginosa PAO1 2.16 X-RAY DIFFRACTION 90.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 500 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000423 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Psest_0314

Human Homologs

Ensembl 110, assembly GRCh38.p14
adenosylhomocysteinase [Source:HGNC Symbol;Acc:HGNC:343]
E-value: 3.2e-133
Percent Identity: 55.2

References

No references are associated with this feature.