Pseudomonas syringae pv. tomato DC3000, PSPTO_5068 (ahcY)

Gene Feature Overview

Strain	Pseudomonas syringae pv. tomato DC3000 (Buell et al., 2003) GCF_000007805.1|latest
Locus Tag	PSPTO_5068
NCBI Old Locus Tag	PSPTO5068
Name	ahcY Synonym: PSPTO5068
Replicon	chromosome
Genomic location	5771439 - 5772848 (+ strand)

Cross-References

RefSeq	NP_794800.1
GI	28872181
Entrez	1186753
INSDC	AAO58495.1
NCBI Locus Tag	PSPTO_5068
NCBI Old Locus Tag	PSPTO5068
UniParc	UPI000000953F
UniProtKB Acc	Q87V73
UniProtKB ID	SAHH_PSESM
UniRef100	UniRef100_Q87V73
UniRef50	UniRef50_Q4K4H7
UniRef90	UniRef90_Q4K4H7

Product

Feature Type	CDS
Coding Frame	1
Product Name	adenosylhomocysteinase
Synonyms
Evidence for Translation
Charge (pH 7)	-11.82
Kyte-Doolittle Hydrophobicity Value	-0.145
Molecular Weight (kDa)	51.3
Isoelectric Point (pI)	5.15

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
6F3P	HYDROLASE	11/28/17	Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa in complex with 3'-deoxyadenosine and K+ cation	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.35	X-RAY DIFFRACTION	90.0
7ZD2	HYDROLASE	03/29/22	Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase inhibited by Co2+ ions.	Pseudomonas aeruginosa PAO1	2.16	X-RAY DIFFRACTION	90.0
6F3O	HYDROLASE	11/28/17	Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa complexed with adenine, K+ and Zn2+ cations	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.75	X-RAY DIFFRACTION	90.0
7ZD3	HYDROLASE	03/29/22	Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase inhibited by Zn2+ ions	Pseudomonas aeruginosa PAO1	1.9	X-RAY DIFFRACTION	90.0
7ZD1	HYDROLASE	03/29/22	Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase inhibited by Hg2+ ions	Pseudomonas aeruginosa PAO1	1.56	X-RAY DIFFRACTION	90.0
7ZD4	HYDROLASE	03/29/22	Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase soaked with Cu+ ions	Pseudomonas aeruginosa PAO1	2.14	X-RAY DIFFRACTION	90.0
6F3N	HYDROLASE	11/28/17	Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa cocrystallized with SAH in the presence of K+ and Zn2+ cations	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.85	X-RAY DIFFRACTION	90.0
7ZD0	HYDROLASE	03/29/22	Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase inhibited by Cd2+ ions	Pseudomonas aeruginosa PAO1	1.87	X-RAY DIFFRACTION	90.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 501 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG000423 (537 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPTO_5068 Search term: ahcY Search term: adenosylhomocysteinase

Human Homologs

Ensembl 110, assembly GRCh38.p14

ENSP00000217426 adenosylhomocysteinase [Source:HGNC Symbol;Acc:HGNC:343] E-value: 1.4e-133 Percent Identity: 56.4

References