Pseudomonas savastanoi pv. phaseolicola 1448A, PSPPH_2620 (metH)

Gene Feature Overview

Strain	Pseudomonas savastanoi pv. phaseolicola 1448A GCF_000012205.1|latest
Locus Tag	PSPPH_2620
Name	metH
Replicon	chromosome
Genomic location	3019961 - 3023680 (- strand)

Cross-References

RefSeq	YP_274813.1
GI	71735937
EC Number	2.1.1.13
Entrez	3558295
INSDC	AAZ35701.1
NCBI Locus Tag	PSPPH_2620
UniParc	UPI0000575940
UniProtKB Acc	Q48IG8
UniProtKB ID	Q48IG8_PSE14
UniRef100	UniRef100_Q48IG8
UniRef50	UniRef50_P13009
UniRef90	UniRef90_G8Q6L5

Product

Feature Type	CDS
Coding Frame	1
Product Name	B12-dependent methionine synthase
Synonyms
Evidence for Translation
Charge (pH 7)	-44.55
Kyte-Doolittle Hydrophobicity Value	-0.177
Molecular Weight (kDa)	136058.3
Isoelectric Point (pI)	4.76

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 508 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003557 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PSPPH_2620 Search term: metH Search term: B12-dependent methionine synthase

Human Homologs

Ensembl 110, assembly GRCh38.p14	ENSP00000506327 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 48.3
Ensembl 110, assembly GRCh38.p14	ENSP00000502299 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 54.3
Ensembl 110, assembly GRCh38.p14	ENSP00000505600 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 52.0
Ensembl 110, assembly GRCh38.p14	ENSP00000355536 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 54.5
Ensembl 110, assembly GRCh38.p14	ENSP00000506109 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 51.0
Ensembl 110, assembly GRCh38.p14	ENSP00000441845 5-methyltetrahydrofolate-homocysteine methyltransferase [Source:HGNC Symbol;Acc:HGNC:7468] E-value: 0.0e+00 Percent Identity: 51.9

References