Pseudomonas aeruginosa PACS2, A0K_RS08675
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PACS2
GCF_000168335.1|latest |
| Locus Tag |
A0K_RS08675
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 1812333 - 1814249 (- strand) |
Cross-References
| RefSeq | ZP_01364519.1 |
| GI | 107100601 |
| NCBI Locus Tag | A0K_RS08675 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
exotoxin A
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -16.15 |
| Kyte-Doolittle Hydrophobicity Value | -0.276 |
| Molecular Weight (kDa) | 69.3 |
| Isoelectric Point (pI) | 5.30 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 1ZM4 | BIOSYNTHETIC PROTEIN/TRANSFERASE | 05/10/05 | Structure of the eEF2-ETA-bTAD complex | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 2.9 | X-RAY DIFFRACTION | 99.0 |
| 2ZIT | BIOSYNTHETIC PROTEIN/TRANSFERASE | 02/24/08 | Structure of the eEF2-ExoA-NAD+ complex | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 3 | X-RAY DIFFRACTION | 99.0 |
| 1XK9 | TRANSFERASE | 09/28/04 | Pseudomanas exotoxin A in complex with the PJ34 inhibitor | Pseudomonas aeruginosa | 2.1 | X-RAY DIFFRACTION | 99.1 |
| 1IKQ | TRANSFERASE | 05/04/01 | Pseudomonas Aeruginosa Exotoxin A, wild type | Pseudomonas aeruginosa | 1.62 | X-RAY DIFFRACTION | 99.2 |
| 1ZM3 | BIOSYNTHETIC PROTEIN/TRANSFERASE | 05/10/05 | Structure of the apo eEF2-ETA complex | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 3.07 | X-RAY DIFFRACTION | 99.0 |
| 1DMA | ADP-RIBOSYLATION | 04/28/95 | DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH NICOTINAMIDE AND AMP | Pseudomonas aeruginosa | 2.5 | X-RAY DIFFRACTION | 99.1 |
| 1ZM2 | BIOSYNTHETIC PROTEIN/TRANSFERASE | 05/10/05 | Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 3.07 | X-RAY DIFFRACTION | 99.0 |
| 1AER | ADP-RIBOSYLATION | 12/11/95 | DOMAIN III OF PSEUDOMONAS AERUGINOSA EXOTOXIN COMPLEXED WITH BETA-TAD | Pseudomonas aeruginosa | 2.3 | X-RAY DIFFRACTION | 99.0 |
| 6EDG | TRANSFERASE | 08/09/18 | Pseudomonas exotoxin A domain III T18H477L | Pseudomonas aeruginosa | 1.47 | X-RAY DIFFRACTION | 96.7 |
| 1ZM9 | BIOSYNTHETIC PROTEIN/TRANSFERASE | 05/10/05 | Structure of eEF2-ETA in complex with PJ34 | Pseudomonas aeruginosa; Saccharomyces cerevisiae | 2.8 | X-RAY DIFFRACTION | 99.0 |
| 1IKP | TRANSFERASE | 05/04/01 | Pseudomonas Aeruginosa Exotoxin A, P201Q, W281A mutant | Pseudomonas aeruginosa | 1.45 | X-RAY DIFFRACTION | 98.9 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE | DB08348 | DrugBank | 5.1.4 | Q5EK40 | Cholix toxin | 32.8 | 693 | 1.8e-84 |
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001108 (295 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: A0K_RS08675
Search term: exotoxin A
|
Human Homologs
References
No references are associated with this feature.