Pseudomonas aeruginosa PACS2, A0K_RS12540
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PACS2
GCF_000168335.1|latest |
| Locus Tag |
A0K_RS12540
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 2632735 - 2633358 (+ strand) |
Cross-References
| RefSeq | ZP_01365254.1 |
| GI | 107101336 |
| NCBI Locus Tag | A0K_RS12540 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
isochorismatase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -3.89 |
| Kyte-Doolittle Hydrophobicity Value | -0.094 |
| Molecular Weight (kDa) | 23.2 |
| Isoelectric Point (pI) | 5.63 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 1NF8 | HYDROLASE | 12/13/02 | Crystal structure of PhzD protein active site mutant with substrate | Pseudomonas aeruginosa | 1.6 | X-RAY DIFFRACTION | 99.5 |
| 1NF9 | HYDROLASE | 12/13/02 | Crystal Structure of PhzD protein from Pseudomonas aeruginosa | Pseudomonas aeruginosa | 1.5 | X-RAY DIFFRACTION | 100.0 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| Isochorismic Acid | DB02793 | DrugBank | 5.1.4 | Q7DC80 | Phenazine biosynthesis protein PhzD | 100.0 | 207 | 3.6e-116 |
| Formic acid | DB01942 | DrugBank | 5.1.4 | Q7DC80 | Phenazine biosynthesis protein PhzD | 100.0 | 207 | 3.6e-116 |
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001494 (1079 members) |
| Putative Inparalogs |
1 predicted inparalogs isochorismatase (A0K_RS25260) 100.0% identity |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: A0K_RS12540
Search term: isochorismatase
|
Human Homologs
References
No references are associated with this feature.