Pseudomonas aeruginosa PACS2, A0K_RS24325
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PACS2
GCF_000168335.1|latest |
| Locus Tag |
A0K_RS24325
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 5195584 - 5196111 (+ strand) |
Cross-References
| RefSeq | ZP_01367463.1 |
| GI | 107103545 |
| NCBI Locus Tag | A0K_RS24325 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
inorganic pyrophosphatase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -6.08 |
| Kyte-Doolittle Hydrophobicity Value | -0.142 |
| Molecular Weight (kDa) | 19.4 |
| Isoelectric Point (pI) | 4.86 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 4XEL | HYDROLASE | 12/24/14 | Crystal structure of Inorganic pyrophosphatase (PPase) from Pseudomonas aeruginosa | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) | 2 | X-RAY DIFFRACTION | 100.0 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| 5-amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile | DB07291 | DrugBank | 5.1.4 | Q3JUV5 | Inorganic pyrophosphatase | 62.9 | 175 | 3.4e-59 |
| N-(pyridin-3-ylmethyl)aniline | DB06851 | DrugBank | 5.1.4 | Q3JUV5 | Inorganic pyrophosphatase | 62.9 | 175 | 3.4e-59 |
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001653 (535 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: A0K_RS24325
Search term: inorganic pyrophosphatase
|
Human Homologs
References
No references are associated with this feature.