Pseudomonas aeruginosa PACS2, A0K_RS28990

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa PACS2
GCF_000168335.1|latest
Locus Tag
A0K_RS28990
Name
Replicon chromosome
Genomic location 6219072 - 6221678 (+ strand)

Cross-References

RefSeq ZP_01368342.1
GI 107104424
NCBI Locus Tag A0K_RS28990

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphomannomutase
Synonyms
Evidence for Translation
Charge (pH 7) -10.75
Kyte-Doolittle Hydrophobicity Value -0.065
Molecular Weight (kDa) 50.3
Isoelectric Point (pI) 4.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2FKM ISOMERASE 01/04/06 PMM/PGM S108D mutant with alpha-d-glucose 1,6-bisphosphate bound Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 99.8
2FKF ISOMERASE 01/04/06 Phosphomannomutase/Phosphoglucomutase from Pseudomonas aeruginosa with alpha-D-glucose 1,6-bisphosphate bound Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 100.0
2H5A ISOMERASE 05/25/06 Complex of the enzyme PMM/PGM with xylose 1-phosphate Pseudomonas aeruginosa 1.72 X-RAY DIFFRACTION 99.8
1P5G ISOMERASE 04/26/03 Enzyme-ligand complex of P. aeruginosa PMM/PGM Pseudomonas aeruginosa 1.61 X-RAY DIFFRACTION 100.0
2H4L ISOMERASE 05/24/06 Complex of PMM/PGM with ribose 1-phosphate Pseudomonas aeruginosa 2.4 X-RAY DIFFRACTION 99.8
4IL8 ISOMERASE 12/29/12 Crystal structure of an H329A mutant of p. aeruginosa PMM/PGM Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 99.6
3RSM ISOMERASE 05/02/11 Crystal structure of S108C mutant of PMM/PGM Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.6
1PCJ ISOMERASE 05/16/03 Enzyme-ligand complex of P. aeruginosa PMM/PGM Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 100.0
1K35 ISOMERASE 10/01/01 Crystal Structure of Phosphomannomutase/Phosphoglucomutase from P.aeruginosa Pseudomonas aeruginosa 2.2 X-RAY DIFFRACTION 100.0
3C04 ISOMERASE 01/18/08 Structure of the P368G mutant of PMM/PGM from P. aeruginosa Pseudomonas aeruginosa 2.2 X-RAY DIFFRACTION 99.8
1P5D ISOMERASE 04/25/03 Enzyme-ligand complex of P. aeruginosa PMM/PGM Pseudomonas aeruginosa 1.6 X-RAY DIFFRACTION 100.0
4MRQ ISOMERASE 09/17/13 Crystal Structure of wild-type unphosphorylated PMM/PGM Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 100.0
3BKQ ISOMERASE 12/07/07 Structure of the P368G mutant of PMM/PGM in complex with its substrate Pseudomonas aeruginosa 2.05 X-RAY DIFFRACTION 99.8
1PCM ISOMERASE 05/16/03 Enzyme-ligand complex of P. aeruginosa PMM/PGM Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 100.0
1K2Y ISOMERASE 09/30/01 Crystal Structure of Phosphomannomutase/Phosphoglucomutase S108A mutant from P. aeruginosa Pseudomonas aeruginosa 1.75 X-RAY DIFFRACTION 99.8

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
D-Mannose 1-Phosphate DB02867 DrugBank 5.1.4 P26276 Phosphomannomutase/phosphoglucomutase 100.0 463 7.4e-271
alpha-D-glucose-1-phosphate DB02843 DrugBank 5.1.4 P26276 Phosphomannomutase/phosphoglucomutase 100.0 463 7.4e-271
alpha-D-mannose 6-phosphate DB02900 DrugBank 5.1.4 P26276 Phosphomannomutase/phosphoglucomutase 100.0 463 7.4e-271
Dexfosfoserine DB04522 DrugBank 5.1.4 P26276 Phosphomannomutase/phosphoglucomutase 100.0 463 7.4e-271
alpha-D-glucose 6-phosphate DB02007 DrugBank 5.1.4 P26276 Phosphomannomutase/phosphoglucomutase 100.0 463 7.4e-271

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004893 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: A0K_RS28990

Human Homologs

References

No references are associated with this feature.