Pseudomonas aeruginosa PAO1, PA5272 (cyaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA5272
Name
cyaA
Replicon chromosome
Genomic location 5936370 - 5939222 (+ strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253959.1
GI 15600465
Affymetrix PA5272_cyaA_at
Entrez 877744
GenBank AAG08657.1
INSDC AAG08657.1
NCBI Locus Tag PA5272
protein_id(GenBank) gb|AAG08657.1|AE004940_1|gnl|PseudoCAP|PA5272
TIGR NTL03PA05273
UniParc UPI00000C5F81
UniProtKB Acc Q9HTS8
UniProtKB ID Q9HTS8_PSEAE
UniRef100 UniRef100_Q9HTS8
UniRef50 UniRef50_Q9HTS8
UniRef90 UniRef90_Q9HTS8

Product

Feature Type CDS
Coding Frame 1
Product Name
adenylate cyclase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.35
Kyte-Doolittle Hydrophobicity Value -0.387
Molecular Weight (kDa) 108.7
Isoelectric Point (pI) 6.78

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse model of acute pneumonia
Reference 14977975

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 63 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004850 (544 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5272
Search term: cyaA
Search term: adenylate cyclase

Human Homologs

References

Cloning and promoter analysis of the Escherichia coli adenylate cyclase gene.
Aiba H, Kawamukai M, Ishihama A
Nucleic Acids Res 1983 Jun 11;11(11):3451-65
PubMed ID: 6344011
Phylogeny of adenylyl cyclases.
Danchin A
Adv. Second Messenger Phosphoprotein Res. 1993 ;27
PubMed ID: 8418825
Bacterial adenylyl cyclases.
Peterkofsky A, Reizer A, Reizer J, Gollop N, Zhu PP, Amin N
Prog. Nucleic Acid Res. Mol. Biol. 1993 ;44
PubMed ID: 8434125