Pseudomonas aeruginosa PAO1, PA5213 (gcvP1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006563 L-serine metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0019464 glycine decarboxylation via glycine cleavage system
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 3023185 Reviewed by curator
Molecular Function GO:0045135 poly(beta-D-mannuronate) lyase activity
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0006544 glycine metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0006566 threonine metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Molecular Function GO:0004375 glycine dehydrogenase (decarboxylating) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00613
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006544 glycine metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00461
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006546 glycine catabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:cd00613
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class
Central intermediary metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00630 Glyoxylate and dicarboxylate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glycine, serine and threonine metabolism ECO:0000037
not_recorded
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd00613 GDC-P IPR020581 Glycine cleavage system P protein 66 441 0.0
FunFam G3DSA:3.90.1150.10:FF:000007 Glycine dehydrogenase (decarboxylating), mitochondrial - - 767 904 1.2E-65
Gene3D G3DSA:3.40.640.10 - IPR015421 Pyridoxal phosphate-dependent transferase, major domain 515 771 7.8E-87
CDD cd00613 GDC-P IPR020581 Glycine cleavage system P protein 484 873 0.0
FunFam G3DSA:3.40.640.10:FF:000007 glycine dehydrogenase (Decarboxylating), mitochondrial - - 523 757 3.0E-124
PANTHER PTHR11773 GLYCINE DEHYDROGENASE, DECARBOXYLATING IPR020581 Glycine cleavage system P protein 6 956 0.0
FunFam G3DSA:3.40.640.10:FF:000005 Glycine dehydrogenase (decarboxylating), mitochondrial - - 97 355 0.0
NCBIfam TIGR00461 JCVI: aminomethyl-transferring glycine dehydrogenase IPR003437 Glycine dehydrogenase (decarboxylating) 19 950 0.0
Pfam PF02347 Glycine cleavage system P-protein IPR020581 Glycine cleavage system P protein 18 441 0.0
SUPERFAMILY SSF53383 PLP-dependent transferases IPR015424 Pyridoxal phosphate-dependent transferase 473 951 1.03E-96
SUPERFAMILY SSF53383 PLP-dependent transferases IPR015424 Pyridoxal phosphate-dependent transferase 19 442 5.68E-97
Gene3D G3DSA:3.40.640.10 - IPR015421 Pyridoxal phosphate-dependent transferase, major domain 97 355 1.1E-83
Hamap MF_00711 Glycine dehydrogenase (decarboxylating) [gcvP]. IPR003437 Glycine dehydrogenase (decarboxylating) 10 956 25.760927
Gene3D G3DSA:3.90.1150.10 Aspartate Aminotransferase, domain 1 IPR015422 Pyridoxal phosphate-dependent transferase, small domain 772 905 1.1E-40

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.