Pseudomonas aeruginosa PAO1, PA5386 (cdhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0042413 carnitine catabolic process
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 19406895 Reviewed by curator
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00725
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016491 oxidoreductase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:1.10.1040.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0070403 NAD+ binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02737
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006631 fatty acid metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF02737
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class
Putative enzymes Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc PWYB-96 Carnitine Catabolism to Glycine Betaine 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 6 185 9.86E-46
FunFam G3DSA:3.40.50.720:FF:000522 L-carnitine dehydrogenase - - 4 188 1.6E-112
Gene3D G3DSA:3.40.50.720 - - - 4 188 4.0E-47
SUPERFAMILY SSF48179 6-phosphogluconate dehydrogenase C-terminal domain-like IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily 188 275 1.28E-14
Gene3D G3DSA:1.10.1040.10 - IPR013328 6-phosphogluconate dehydrogenase, domain 2 189 310 1.8E-27
Hamap MF_02129 L-carnitine dehydrogenase [lcdH]. IPR026578 L-carnitine dehydrogenase 8 318 54.179604
Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding 11 184 6.3E-39
Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal 188 256 1.0E-14
FunFam G3DSA:1.10.1040.10:FF:000027 L-carnitine dehydrogenase - - 189 310 5.4E-70
PIRSF PIRSF000105 HCDH IPR022694 3-hydroxyacyl-CoA dehydrogenase 4 301 2.7E-55
PANTHER PTHR48075 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN - - 6 295 5.5E-60

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.