Pseudomonas aeruginosa PAO1, PA5386 (cdhA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5386
Name
cdhA
Replicon chromosome
Genomic location 6063883 - 6064848 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentDeletion of cdhA or transposon insertion into the coding sequence results in a strain unable to grow using L-carnitine as a sole carbon source. Deletion of cdhCA results in complete loss of carnitine dehydrogenase activity as measured by carnitine-dependent NADH formation from cytoplasmic extracts.

Cross-References

RefSeq NP_254073.1
GI 15600579
Affymetrix PA5386_at
Entrez 881645
GenBank AAG08771.1
INSDC AAG08771.1
NCBI Locus Tag PA5386
protein_id(GenBank) gb|AAG08771.1|AE004951_5|gnl|PseudoCAP|PA5386
TIGR NTL03PA05387
UniParc UPI00000C5FD7
UniProtKB Acc Q9HTH8
UniProtKB ID LCDH_PSEAE
UniRef100 UniRef100_Q9HTH8
UniRef50 UniRef50_D7URM0
UniRef90 UniRef90_Q9HTH8

Product

Feature Type CDS
Coding Frame 1
Product Name
CdhA, Carnitine dehydrogenase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -7.16
Kyte-Doolittle Hydrophobicity Value 0.089
Molecular Weight (kDa) 34.7
Isoelectric Point (pI) 5.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 435 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004945 (484 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5386
Search term: cdhA

Human Homologs

Ensembl 110, assembly GRCh38.p14
crystallin lambda 1 [Source:HGNC Symbol;Acc:HGNC:18246]
E-value: 1.7e-32
Percent Identity: 30.2

References

No references are associated with this feature.